DUBAI, United Arab Emirates (AP) — The U.S. military said Saturday that it had launched new airstrikes against Iran to “swiftly punish” the country’s Revolutionary Guard for an attack in Jordan that killed two American service members, left one more missing and four requiring hospitalization.

The U.S. Central Command said the strikes were designed to further degrade Iran’s ability to restrict the traffic of oil tankers through the Strait of Hormuz. The waterway accounted for roughly 20% of global oil supplies before the war.

The U.S. military earlier Saturday announced its first troop deaths due to direct Iranian fire in an attack on a base in Jordan after days of intensifying exchanges of fire

The dead were not identified. Since the war began, 16 U.S. service members have been killed and over 430 wounded.

Minutes before the announcement, Iran’s supreme leader warned of “unforgettable lessons” if the U.S. keeps attacking the Islamic Republic. The remarks read out on state TV and attributed to Mojtaba Khamenei, still unseen since the war began, also called President Donald Trump’s signature “worthless and invalid.”

The comments came hours after a negotiator said Tehran was suspending its commitments to the interim deal signed about a month ago and aimed at permanently ending the fighting.

Tehran's declarations snapped another fragile thread as the war shows no end in sight. Now Khamenei warns of “lessons” not only from Iran but its armed proxies in the region, calling them the “Axis of Resistance."

The battle over the Strait of Hormuz has intensified in a conflict increasingly focused on control of the essential waterway that previously carried a fifth of the world's crude oil. The strikes threaten civilians and infrastructure, including desalination plants for drinking water, while the global economy again is on alert.

The U.S. has violated its commitments under the deal that was signed about a month ago and now Iran is “no longer implementing them,” Kazem Gharibabadi, Iran’s deputy foreign minister, told state TV.

There was no new word on mediation efforts.

U.S. soldiers see growing risks

The previous recorded death of a U.S. service member was that of a helicopter pilot who crashed in the Arabian Sea earlier this month. Early in the war, an Iranian drone strike on a command center in Kuwait killed six soldiers. One soldier died after an attack on a base in Saudi Arabia. Six were killed when a refueling aircraft crashed in Iraq.

The most significant damage on Saturday occurred in Kuwait when Iran struck a water desalination plant and an oil facility, according to the Kuwait authorities and the Kuwait Petroleum Corporation. Both declined to provide locations.

The strikes injured several people at the oil facility and caused a fire at the desalination plant, forcing several power generation units offline. It was the second attack against a desalination plant in two days in the tiny desert nation that depends on desalination for 90% of its drinking water.

Several firefighters and a worker were injured while battling two other blazes sparked by Iranian strikes, according to the Kuwait Fire Force. Kuwait briefly closed its airspace due to missile threats, and Kuwait Airways said it was rescheduling most flights to and from the capital.

Meanwhile, Iraq said it shot down attack drones over the city of Irbil. Jordan’s state-run Petra news agency said the kingdom’s air defense systems had downed Iranian missiles, while air sirens sounded multiple times in Bahrain throughout the day and in Saudi Arabia in the morning, according to their governments.

The secretary general of the six-nation Gulf Cooperation Council, Jasem Mohamed al-Budaiwi, accused Iran of war crimes for strikes on infrastructure and civilian facilities.

U.S. strikes hit infrastructure in Iran

The U.S. Central Command said early Saturday that its seventh straight night of strikes hit “surveillance sites, military logistics infrastructure, underground weapons storage, and maritime capabilities.”

U.S. airstrikes hit an electricity and desalination plant in Iran’s southern Hormozgan province, Iranian state TV reported. The Islamic Republic News Agency said the Bonji desalination plant was destroyed, cutting off water supplies to about 10,000 people, and that a desalination plant on strategic Qeshm Island inside the strait was damaged.

Overnight strikes damaged two tunnels and a bridge, disrupting one of the main highways toward Bandar Abbas, Iran’s main port that sits near the narrowest part of the strait, according to the news agency. IRNA said three bridges were hit Saturday, including one on a route to Bandar Abbas.

Iran acknowledged “attacks on power infrastructure” during the U.S. airstrikes for the first time Friday when its Energy Ministry issued a call for people to use less power in southern provinces “experiencing extreme heat.” It did not specify what was hit.

Iranian authorities said at least 50 people have been killed and more than 500 wounded in U.S. strikes in the past three weeks, including eight killed in a strike on a bridge Friday.

Iran and U.S. vie for Strait of Hormuz

Iran effectively closed the strait to shipping traffic after the war started with U.S. and Israeli strikes on Feb. 28. That sent the price of oil soaring and has given Tehran significant leverage in negotiations.

Iran has said the strait must be under its sole control and that vessels should pay fees to Tehran, even though the world for decades has considered it an international waterway. It fired on ships on recent days. Crossings through the strait fell to a three-week low, according to an international shipping tracker.

Trump has resumed threats to target power stations and bridges to try to compel Iran to loosen its hold. The U.S. in the past week reimposed a naval blockade on Iranian ports to halt its shipments of crude oil.

A growing amount of the region’s energy is being shipped through pipelines, but not nearly enough to offset the decline in shipping.

Before the war began, the U.S. had been in talks with Iran over its nuclear program. Trump now faces political pressure to end the war and avoid the kind of prolonged Middle East conflict he had campaigned against.